Monday, October 06, 2014

Thomas Eric Duncan, Texas Ebola Patient Fighting For Life With US Drug Finished As Scientists Predict 75% Chance Ebola Will Reach France, 50% For UK By End October


Workers dressed in hazardous material suits stand at the apartment unit where a man diagnosed with the Ebola virus was staying in Dallas, Texas, October 5, 2014.(Reuters / Jim Young)

The first patient to be diagnosed with Ebola in the US is in critical condition at a Dallas hospital and is not receiving any of the new experimental drugs for the virus, which has killed over 3,400 people in Africa, media reports say.

Thomas Eric Duncan contracted the disease in Liberia and began to show symptoms after arriving in Texas two weeks ago, causing a panic that he could have infected another 10 individuals.

Dr. Thomas Frieden, director of the US Centres for Disease Control and Prevention (CDC), said Duncan is in critical condition, adding that the patient is not receiving ZMapp – an experimental medicine – because it is “all gone” and is “not going to be available anytime soon.”

The comments were made during a briefing with reporters on Sunday. 
Screengrab of the house in which Thomas Eric Duncan was staying in Texas. Credits: abcnews.com

Speaking on another experiential drug produced by Canada’s Tekmira Pharmaceuticals Corp, Frieden described the treatment as “difficult for patients to take.”

The decision whether to give this drug to the patient will be made by his doctor and family members, but “access” to the medicine will be made available.

“As far as we understand, experimental medicine is not being used,” Frieden said. “It’s really up to his treating physicians, himself, his family what treatment to take.”

Outbreak risks

Duncan’s case has sparked fears of Ebola spreading across the US, particularly due to the fact that the Dallas hospital failed to diagnose the virus the first time around and sent the patient home with antibiotics.

“The issue of the missed diagnosis initially is concerning,” Frieden told CNN’s State of the Union. “We’re seeing more people calling us, considering the possibility of Ebola – that’s what we want to see. We don’t want people not to be diagnosed.”

Frieden added that it was unlikely for the disease to spread widely across the US.

US health officials are currently monitoring 10 quarantined people who had contact with Duncan. The individuals are considered to be “high risk,” and are being checked at regular intervals for symptoms of the disease.

Another 38 were previously being observed as potential contacts. The original list of all the people Duncan had contact with included 114 individuals.

In the meantime, the state of Nebraska is getting ready to receive a US Ebola patient who also became infected in Liberia, Reuters quoted Nebraska Medical Center spokesman Taylor Wilson as saying on Sunday.

Wilson identified the patient as male, refusing to provide any further details. However, Reuters reported that the patient might be a freelance cameraman working for NBC News, Ashoka Mukpo, citing the father of the individual.

Ashoka Mukpo, 33, (L) became the fifth American diagnosed with Ebola, it was announced Thursday, after he begun working as a freelance cameraman for NBC News this week. The revelation has left his family and friends reeling — knowing how he was willing to be in the epicenter of an illness that has killed more than 3,000 people in West Africa.

Meanwhile scientists estimate there’s a 75% chance the Ebola virus could spread to France and as 50% chance it could reach UK by the end of October. The latest research analyzes the pattern of infection and airline traffic.

The consensus among health officials is now that the deadly virus is no longer just an African problem, and key to this assessment are the European Union’s free movement policy and the deceptive incubation period, allowing the person to spread the infection unaware.

France has the worst statistics out of all the European countries because the worst-hit countries in Africa are French-speaking, including Guinea, Sierra Leone and Liberia, according to the study ‘Assessing the International Spreading Risk Associated with the 2014 West African Ebola Outbreak’.

"If this thing continues to rage on in West Africa and indeed gets worse, as some people have predicted, then it's only a matter of time before one of these cases ends up on a plane to Europe,” expert in viruses from Britain's Lancaster University, Derek Gatherer, said.

The next country on the list after France and the UK is Belgium, with a 40% chance of infection. Meanwhile, Spain and Switzerland face smaller risks of the virus breaching its borders with 14 per cent.

One of the key elements in analyzing the spread of the disease is air traffic, the leader behind the research, Alex Vespignani, from Northeastern University in Boston told Reuters.

"Air traffic is the driver," Vespignani said. "But there are also differences in connections with the affected countries (Guinea, Liberia and Sierra Leone), as well as different numbers of cases in these three countries - so depending on that, the probability numbers change."

While Vespignani admits the model is inconclusive, and could widen to include others, one thing is certain: the probability of contracting the virus is growing for everyone, “it’s just a matter of who gets lucky and who gets unlucky.”

Paris, France (Reuters / Charles Platiau)

Despite approaching the disease with extreme caution, the World Health Organization (WHO) placed no restrictions on flights to the worst-affected countries. And while British Airways and Emirates are no longer flying there, Air France has only suspended flights to Sierra Leone – not Liberia, Guinea or Nigeria (though air crews were recently offered the option to refuse flying to those destinations).

But the strategy for combating the virus isn’t only dependent on air traffic regulations. The most dangerous contributor to the spread is the behaviour of the virus. Its symptoms catch people unawares and normally follow a 21-day incubation period, during which there’s literally no visible sign the person has contracted Ebola.

This allows for circulation of sick passengers and is presumably how Liberian Thomas Eric Duncan was allowed to enter the US and remain there for several days with no knowledge of his condition.

This is further complicated by the EU’s free movement system – one can literally infect anyone they come into contact with in the space of a few days if they were to drive or fly from one country to another.

Airport screenings aren’t effective 100% of the time, due to patients using fever-reducing drugs or simply lying to get on the plane, as well as airport staff lacking competence in the field.

The only mitigating factor here is that the disease is at its most contagious when the associated symptoms of profuse vomiting and diarrhoea begin to manifest themselves, which occurs when the disease reaches terminal stage. By then, the patient is quickly isolated from the public.

But the prospects aren’t as grim when considering that the EU is mostly comprised of very well-developed countries. The ability to have a coordinated approach to the problem greatly lowers the risk and is “considered to be sufficient to interrupt any possible local transmission of the disease early," according to the latest assessment from the European Centres of Disease Prevention and Control.

This can be witnessed in Nigeria, which, despite its worst-hit neighbours in West Africa, still managed to stem the flow of infection to only 20 cases and eight deaths. The country is already on its way to being declared Ebola-free in a matter of weeks.

"Even if we have a worst-case scenario where someone doesn't present for medical treatment, or… it's not correctly identified as Ebola, and we get secondary transmission, it's not likely to be a very long secondary transmission chain," Gatherer says.

This is further helped by Europe’s “very sanitized, sterile lives” and the fact that it’s a much less crowded environment than the poverty-stricken settlements where infection is generally rife.

The new study comes as an Ebola-infected US citizen struggles for survival in a Texas hospital.

The Ebola virus has so far taken the lives of over 3,400 people since March and has been declared the worst epidemic in history.
Symptoms of the deadly Ebola virus, which has hit the West African countries of Liberia, Sierra Leone, and Guinea, include fever, vomiting, and diarrhoea. The disease is contagious and is acquired through contact with bodily fluids such as blood or saliva.

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