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United States Military
Defense Advance Research
Projects Agency
(DARPA says they may
have a method to stop all infectious diseases - including Ebola. By
encoding RNA and DNA in a specific way, Darpa say a person could simply go into
a shop and get an injection to protect them against a disease (SEE FULL ARTICLE HERE).
This
could be used to prevent mass outbreaks in affected areas.
FUSION report continues:
‘We’re going to take the genetic code and put
it into a format where you go to your drug store or doctor and get a shot in
the arm,’ said DARPA programme manager Dan Wattendorf at an event in San
Francisco. ‘There’s a low-cost of goods, no cold chain,
and we would produce the correct antibody in [any] individual directly.’
The
method works by creating powerful antibodies from survivors of an infectious
disease.
‘Instructions’
on how to make these antibodies are then encoded into RNA and DNA, which are
injected into people who might come into contact with the disease.
Their
cells then start creating the antibodies, protecting them from catching the
potentially dangerous disease.
DARPA
is currently funding the project through Emory University in Atlanta.
Experts
say the method, if proven to be safe and effective, would be faster and cheaper
than conventional drug production and could potentially be used to treat
illnesses such as seasonal flu or malaria.
Antibodies
are typically grown in large vats of mammal cells or in some cases, tobacco
plants, such as US pharmaceutical company Mapp Biopharmaceutical's experimental
Ebola treatment ZMapp.
DARPA
has awarded Emory up to £7.3 million (US$10.8 million) over three years to direct
the project.
Emory
is using blood samples from the Ebola outbreak in West Africa to test the
method.
Initially,
the technology was being developed in hopes of protecting soldiers from
seasonal flu or germs that cause diarrhea on the battlefield, but the Ebola
outbreak presented an opportunity to accelerate the research.
To
succeed, researchers will need to identify an effective delivery system to
carry the genetic instructions into the body and learn how to quickly identify
the most protective antibodies.
The
goal is to get the process down to 90 days for most diseases.
The
group is in the process of characterizing several Ebola antibody candidates to
find which are the most potent. At that point, the researchers and DARPA will seek
out drug company partners.
Testing in people could
begin within two years, with the goal of having a better weapon for the next
outbreak - whatever it may be.
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